AM PM Stress & Anxiety

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Herbal Information:

Valerian Root:

  • This herb has a long history of being used for many health conditions.
  • Valerian Root has a history of being used as a sleep aid, for anxiety relief. Greek physicians Dioscorides and Galen touted it as a remedy for poison. It was used as a cure for epilepsy in the Middle Ages.
  • The most common historical use for Valerian is as a treatment for nervous disorders. There are current studies that are testing the efficacy of Valerian Root for different nervous system issues.
  • In the 16th century Valerian was used to treat nervousness, trembling and headaches.
  • Most studies seem to indcate that Valerian has two active componants that contribute to its effectiveness.
    • First is valerenic acid and its derivatives, which have demonstrated sedative properties in animal studies (Hendriks H, Bos R, Allersma DP, Malingre M, Koster AS: Pharmacological screening of valerenal and some other components of essential oil of Valeriana officinalis. Planta Medica 42: 62-68, 1981)
    • And second are the iridoids, which include the valepotriates. Valepotriates and their derivatives are active as sedatives in vivo.
      • Both of these seem to act as a sedative individually however there are other componants in Valerian that also have effects on the nervous system without the inclusion of valerenic acid or valerian iridoids. It may be possible that there are more nervous system active componants still left to study.
  • A possible mechanism by which a valerian extract may cause sedation is by increasing the amount of gamma aminobutyric acid (GABA, an inhibitory neurotransmitter) available in the synaptic cleft. Studies are still needed to prove or disprove this theory.

St John's Wort:

  • St. John’s wort (Hypericum perforatum), a plant that grows in the wild, has been used for centuries for mental health conditions. It’s widely prescribed for depression in Europe.
  • According to the National Institute of Health "A 2008 review of 29 international studies suggested that St. John’s wort may be better than a placebo and as effective as different standard prescription antidepressants for major depression of mild to moderate severity. St. John’s wort also appeared to have fewer side effects than standard antidepressants. The studies conducted in German-speaking countries—where St. John’s wort has a long history of use by medical professionals."
  • The possible mechanism that causes St John's Wort to be an effective as a natural antidepressant is a rare combination of antidepressant chemicals that prevent or delay the re-uptake of the hormones serotonin, dopamine and norepinephrine, thereby reducing depressive symptoms.
    • St. John's Wort has two main active chemicals that are responsible for the re-uptake of seritonin, dopamine and norepinephrine. They are hypericin and pseudohypericin. Both active compounds in St. John's wort that have been shown to fight depression and viral syndromes.
  • A 2017 analysis of 27 studies determined that St. John’s wort had similar effects on mild to moderate depression as antidepressants. Those researchers also noted that fewer people stopped taking St. John’s wort, compared to antidepressants. (NIH Review Link)
  • According to an article posted by Healthline E-magizine; Jeremy Wolf, a licensed naturopathic physician, explained that St. John’s wort creates many actions in the body.
    • “It is a strong antidepressant and may elevate mood in individuals with mild to moderate depression,” he said.
    • He notes that St. John’s wort is not recommended for individuals with severe depression.
    • Wolf said St. John’s wort also has strong antiviral activity that may also promote healing and repair of wounds.
    • He cautioned that the herb is not a fast-acting cure. It may take weeks or months before you notice any effect.
  • Studies have shown that the Hypericum plant, also known as St. John's wort, has mild antidepressant effects. Standardized formulations are supposed to contain 0.3% hypericin, the plant extract. However, few published studies have examined commercially available products for the amounts of hypericin and pseudohypericin -- both active compounds in St. John's wort that have been shown to fight depression and viral syndromes.


  • Hops contain a flavonoid compound, xanthohumol, that may have antiviral, anti-clotting, anti-inflammatory, and anti-tumor activity.
  • Hops contain chemicals that have sedative effects.
    • These chemicals may be beneficial in relieving anxiety and to induce relaxation and sleep. This has been confirmed by a study published in Phytomedicine, 2006 where it has been reported that the ethanolic and CO2 extracts from hops reduced the locomotor activity and body temperature while increasing the ketamine-induced sleep confirming the central sedative effects of hops. (Report Link)
  • Hops have been used historically to promote sleep, often in combination with the sedative herb valerian. The effectiveness of this combination has been validated in a number of placebo-controlled studies. (Uwe Koetter and Martin Biendl, “Hops (Humulus lupulus): A Review of its Historic and Medicinal Uses.” HerbalGram, 2010
  • The concentration of 2 mg of hop extract effectively decreased nocturnal activity in the circadian activity rhythm. On the basis of this investigation... hops content and consequent sedative action would be an aid to nocturnal sleep. (The sedative effects of hops (Humulus lupulus))


  • Historically Skullcap was the go to herb for the relief of anxiety and nervous tension. As one excerpt from an old herbal encyclopaedia puts it, “Skullcap is one of the finest nervines and antispasmodics given to humanity. It should be on every physician’s shelf”.
    • According to Penn State Medical Center. "For around two centuries, it was said that American skullcap was widely used as a mild relaxant and as a form of treatment for anxiety, nervous tension and convulsions".
  • Skullcap has historical roots as a sedative. American skullcap has potential as a treatment for hysteria, panic attacks, anxiety and delirium. It also helps induce sleep naturally in people with insomnia. (Excerpts from Naturally Pain Free: Prevent and Treat Chronic and Acute Pains-Naturally By Letha Hadady)
  • A May 2009 study published in Phytomedicine also highlighted that American skullcap promoted anticonvulsant activities in rats. (Study Link)
  • Oxidative stress is an imbalance between free radicals and antioxidants in your body. It is believed by many researchers that oxidative stress affects some brain-related diseases, such as anxiety, Alzheimer’s disease, depression and Parkinson’s disease. Further research indicates that bioactive compounds found in medicinal plants, such as skullcap, may neutralize and even eliminate toxic free radicals. When this occurs, oxidative stress is greatly reduced. Skullcap may provide significant antioxidant effects, which could make it a great option for reducing anxiety. (NIH Study Abstract)

  • B Vitamins:
    • B Vitamins have been used traditionally as mood leveling supplements. Here at Grandma's Herbs we call them the happy vitamins.
      • A statement issued in a study found on is "After individual differences in personality and work demands were statistically controlled, the vitamin B complex treatment groups reported significantly lower personal strain and a reduction in confusion and depressed/dejected mood after 12 weeks."
    • In a study titled "Reducing occupational stress with a B-vitamin focussed intervention: a randomized clinical trial:" it was concluded that:
      • "Occupational stress is a multibillion dollar problem. Effective strategies reducing occupational stress are urgently required. Dietary supplementation with B group vitamins may be an economically viable and sustainable intervention. Reducing occupational stress will have enormous benefits for decreasing stress claims, absenteeism, and increasing work productivity. Vitamin B supplementation is also likely to have additional health and quality of life benefits."
  • Magnesium:
    • Magnesium is a mineral that plays a role in over 300 enzymatic reactions within the body, including the metabolism of food, synthesis of fatty acids and proteins, and the transmission of nerve impulses.
    • Findings in current studies offer modest support that Magnesium (Mg) intake confers benefits for individuals with pre-existing mild to moderate levels of anxiety. This comes from an analysis of 8 different studies of Magnesium and mild stress/anxiety.(PMC Article Link)
    • Reductions in magnesium levels, or changes in the way that it is processed, have been linked to increased levels of anxiety.
      • This appears to related activity in the hypothalamic-pituitary-adrenal (HPA) axis, a set of three glands that control a person's reaction to stress.
      • Research has shown that a low-magnesium diet may alter the types of bacteria present in the gut, and this may impact anxiety-based behavior. (National Institute of Health Study Publication)
  • GABA (Gamma Aminobutyric Acid):
    • Gamma-aminobutyric acid is a neurotransmitter that helps send messages between the brain and the nervous system. It is produced in the brain from glutamate. This process is catalyzed by the active form of vitamin B6 and the enzyme glutamate decarboxylase.
    • GABA currently being studied for the effects it has in relation to stress and anxiety.
      • "In conclusion, GABA could work effectively as a natural relaxant and its effects could be seen within 1 hour of its administration to induce relaxation and diminish anxiety." ( Article Link)
    • The significance of this key neurotransmitter has just recently been recognized, but it is now thought that it plays a role in a multitude of health conditions, including ADHD, insomnia, depression and anxiety.
    • The mechanism of action is believed to reduce feelings of of anxiety and fear by decreasing neuronal excitability.
  • 5-Hydroxytryptophan (5-HTP):
    • 5-HTP is an amino acid. It is essential for the manufacturing of serotonin in the brain.
      • Serotonin is an important chemical and neurotransmitter in the human body. It is believed to help regulate mood and social behavior.
    • Research done on 5-HTP showed that in a double-blind study, 58 percent of generally anxious patients reported significantly greater reduction in baseline anxiety compared to individuals who received a placebo.
  • Supplementing with 5-HTP can help to treat a number of issues that are associated with anxiety, including trouble sleeping, moodiness and headaches.

    • Is the most abundant and most important mineral in the body, but it is also the mineral most likely to be deficient in the average diet.
    • Calcium is the chief supportive element in bones and teeth. About 99% of the calcium is in the bones and teeth.
    • The remaining 1% circulates in bloodstream, where it performs a variety of important functions. 
      • Calcium is important to neurotransmission, the nervous system and brain function. All of which are related to stress. 

Help Me Choose

Does your life sometimes feel like it's totally out of control?
This day was described to us by a seventh grade teacher? Do you relate to how he felt?

"The kids in my classroom are out of control. I was  late for an administrative report that needed to be finished and turned in - like - yesterday! 
The curriculum I'm required to teach from had a recent required change and I wasn't totally prepared to teach from it in tomorrow's discussions. I feel ovewhelmed and stressed about all of it, to say the least."

Acute Stress is the high tension scenarios that we address almost every day. In some instances this kind of stress can be healthy. It provides us with the opportunity to address each issue and overcome the seemingly life altering issues at hand. The experience provides us with a sense of accomplishment and establishes self worth. One important thing about the short term stressors is that they won't last long and they are resolvable. However, if your life feels over run and out of control like this every day, you may be experiencing long-term or chronic stress. This type of stress can be dangerous to your health if you don’t work to overcome it or cope with its effects.

Big stressors include money troubles, job issues, relationship conflicts, and major life changes, such as the loss of a loved one. Smaller stressors, such as long daily commutes and rushed mornings, can also add up over time. Learning how to recognize sources of stress in your life is the first step in managing them.

There are three main catagories and several sub-catagories that contribute to daily stress and anxiety.
  • Personal Problems:
    • Health:
      • Everything related to our health and the health of others that are in our home seem to cause consternation. Contracting a disease is definately a culprate of causing stress or anxiety. Aging is one of the major ones and yet if you think about it we all age and there's nothing we can do about it. With age comes the loss of mental and physical agility and coping with that can be stressful. If you are a care giver in your household be aware that more than half of the care givers report that they are overwhelmed with the responsibility of taking care of a loved one.
    • Relationships:
      • Arguments with your spouse, parent, or child can increase your stress levels. When you live together, it can be even more stressful. Problems between other members of your family or household can also cause you stress, even when you’re not directly involved.
    • Beliefs:
      • Arguments about personal, religious, or political beliefs can challenge you, especially in situations where you can’t remove yourself from the conflict. Major life events that cause you to question your own beliefs can also cause stress. This is especially true if your beliefs are different from those of the people closest to you.
    • Emotional Issues:
      • When you feel unable to relate to someone, or you need to express your emotions but can’t, it can weigh you down with additional stress. Mental health disorders, including depression and anxiety, only add to the emotional strain. Positive outlets for emotional release and treatment for mental health disorders are important parts of effective stress management.
    • Major Life Changes:
      • The death of a loved one, changing jobs, moving houses, and sending a child off to college are examples of big life changes that can be stressful. Even positive changes, such as retirement or getting married, can cause a significant amount of stress.
    • MONEY!:
      • Face it we all suffer from time to time from the stress that is caused by financial issues. Bad credit, overwhelming credit card debt, the untimely breakdown of a vehicle or a major appliance cause serious amounts of stress. If it's not that it might be "keeping up with the Jones's". That can cause both financial and social stress. Nearly seventy five percent of Americans claim that financial issues are their biggest source of stress and anxiety in their lives.
  • Social Issues:
    • Occupation:
      • It might be that you are bored and under employed or that you have a superior you simply hate to deal with. No matter what it is you are amoung the sixty percent of Americans that decry their job as a cause of stress in their lives.
    • Discrimination:
      • It doesn't matter what the discrimination issue actually is what matters is the amount of stress it infliccts on your life while you are experiencing it. Being discriminated against can cause unbearable stress every day.
    • Environment:
      • The environment is not related to polution in the air or water . Environmental stress comes from the neighbohood you live in and the crime - violence that is associated with it. In that case going home to your "safe Place" to get away from the daily occupational stress that you deal with bears no relief. It might even multiply the amount of stress that you feel.
  • Traumatic Events:
    • Traumatic events are hard to talk about. They are personal experiences that are hard or even impossible to recover from. It might be that you were deployed and experienced something completely unbearable or you may have experienced a violent robbery or rape. These events can cause so much stress that you might suffer from Post Traumatic Stress Disorder (PTSD). Obviously this is stress and anxiety at its most dangerous level.
Identifying the causes of stress in your life is the first step in effective stress management. After you’ve figured out what your stressors are, you can take steps to reduce or avoid them. You can also adopt healthy lifestyle habits and strategies to manage the effects of stress. For example, eating a well-balanced diet, exercising regularly, and getting enough sleep may help you feel more calm, focused, and energized. Practicing relaxation techniques, such as rhythmic breathing, meditation, or yoga, may also help relieve stress and anxiety. To learn more stress management strategies, speak to your doctor or a mental health professional.

Health Information

Are there some drug free ways to manage my stress and anxiety?
There are a great number of things that can be done. Here is a short list.
  • Exercise:
    • Exercise is an important part of physical -- and mental -- health. It can ease your feelings of anxiety and boost your sense of well-being. Shoot for three to five 30-minute workout sessions a week. Be sure to choose exercises you enjoy so you look forward to them.
  • Sleep
    • With your busy schedule, there’s no time for sleep, right? Some workaholics brag about only needing three or four hours of sleep a night, as if to say, “I’m more determined and committed than everyone else.” Sleep is very important! You are human afterall. And humans need sleep to function properly. While you are asleep your mind and body get a chance to shed the tensions built up during the day that become stress and anxiety if allowed. There is an actual rejuvenation that happens during that much needed sleep. DON'T MISS OUT ON IT!
  • Proper Diet:
    • Yes I said it. Diet can either add to or take away from your stress level. There is much to be said about a PROPER diet and not everyone associates diet with stress level. What you eat and how much you eat are important. The starvation diets of yesteryear are actually the cause of stress and consternation. Being over anxious about the next meal because you didn't eat the right portions of proteins and and carbs is definately a cause of added stress. Eating too much works just the same and may lead to obesity and the stress that comes with it.
  • Meditation
    • Meditation can help to slow racing thoughts, making it easier to manage stress and anxiety. A wide range of meditation styles, including mindfulness and meditation during yoga, may help.
      Mindfulness-based meditation is increasingly popular in therapy.
    • According to the American Psychological Society a 2010 analitical review suggests that it can be highly effective for people with disorders relating to mood and anxiety.

      Are there natural supplements that can help with stress?

  • To answer that question it might be best to look at the results of some independant studies.
    • Here are a few natural supplements that appear to have a possitive efffect in relation to stress or anxiety.
    • B Vitamins have been used traditionally as mood leveling supplements. We (here at Grandma's Herbs) call them the happy vitamins.
      • A statement issued in a study found on is "After individual differences in personality and work demands were statistically controlled, the vitamin B complex treatment groups reported significantly lower personal strain and a reduction in confusion and depressed/dejected mood after 12 weeks."
    • Magnesium: Findings to date offer modest support that Mg intake confers benefits for individuals with pre-existing mild to moderate levels of anxiety.
      • This comes from an analysis of 8 different studies of Magnesium and mild stress/ anxiety. ( PMC Article Link )
    • GABA (Gamma Aminobutyric Acid). It is also being studied for the effects it has in relation to stress and anxiety.
      • "In conclusion, GABA could work effectively as a natural relaxant and its effects could be seen within 1 hour of its administration to induce relaxation and diminish anxiety." ( Article Link )
The studies sited above are for informational purposes only. They do not reflect or relate to the performance or purpose of any products that contain similar materials.


  • "B" ALL CALM 
    • Vitamin B1 (as Thiamin), Vitamin B2 (as Riboflavin), Vitamin B3 (as Niacinamide), Vitamin B6 (as Pyridoxine HCL), Folic Acid, Vitamin B12 (as Cobalamin 1%), Biotin (1%), Vitamin B5 (as Pantothenic Acid), Magnesium (as A.A. Chelate), Zinc (as Acetate), Chromium (as Polyniconate 10%) Herbs: St. John's Wort (whole), Ginkgo Biloba (leaf), GABA Inositol (USP), Choline (as Bitartate), Valerian (root), Passion Flower (herb), Griffonia Extract 25% (5-HTP)
    • Red Raspberry (leaf & pulp), Horsetail Grass (herb), Alfalfa (leaf), Oat Straw (herb), Nettle (herb), Barley Green (herb), Aloe Vera (herb), Kelp (herb), Bladder Pod (herb), Parsley (herb)
    • St John's Wort (herb), Valerian (root), Skullcap (herb), Cedar Berries, Black Root (herb), Blue Vervain (herb), Mistletoe (herb), Passion Flower (herb), Wild Yam (root), Peppermint (leaf), Chamomile (herb), Hops Flower (herb), Bladder Pod (herb), Wood Betony (herb), Feverfew (herb), Blue Cohosh (root), Cascara Sagrada (bark), Cayenne (fruit 40 HU)
    • Hops (flower), Valerian (root), Blue Vervain (herb), Skullcap (herb), St John's Wort (herb), Black Cohosh (root), Lady's Slipper (root), Lily of the Valley (herb), Bladder Pod (herb), Mistletoe (herb), Spearmint (leaf)


  • "B" ALL CALM 
    • 2 Capsules each morning with food. Take an additional 4 to 6 per day as needed.
    • 2 or 3 Capsules twice a day.
    • 2 Capsules 1, 2, or 3 times a day as needed.
    • Take 2 to 4 capsules 1 hour before bedtime. You may use more if needed.

What's included

  • One Bottle "B" ALL CALM* - Herbal Remedy for Stress and Anxiety - 100 Capsules - 510 mg.
  • One Bottle HERBAL CALCIUM* - Herbal Remedy for Daily Calcium Supplement - 100 Capsules - 500 mg.
  • One Bottle NATURALL-CALM* - Herbal Remedy for Stress, Depression and Anxiety - 100 Capsules - 500 mg.
  • One Bottle NIGHT NERVINE* - 100 Capsules - 426 mg.


  • "B" ALL CALM
    • Promotes feelings of well-being.
    • Uses studied ingredients like B vitamins, GABA, Magnesium and St John's Wort.
    • Promotes feelings of health, well being and confidence in stressful situations.
    • Calcium that comes from green leafy herbs are absorbed by our body easier.
    • HERBAL CALCIUM delivers the calcium that you need to run, jump and even sleep better.
    • Calcium is one of the most important minerals in the body. Calcium from plants comes in a form that the body can use immediately.
    • St. John's Wort, the main ingredient in Grandma's NaturALL-Calm. Traditionally it has been used for treating anxiety and tension for over 2,000 years.
    • Promotes a healthy attitude and outlook.
    • NaturALL-Calm contains St John's Wort, Valerian Root and Passion Flower. These herbs are traditionally used to promote peace of mind.
    • NaturALL-Calm works well with Grandma’s Herbs Nervine formula or B All Calm formula.
    • We have testimonial after testimonial from our grateful customers! 
    • This Herbal Supplement Soothes Nerves.
    • Natural Herbal Remedy that promotes healthy sleep.
    • Non habit-forming.


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